Researchers have developed and released an innovative software ‘Verkko’ to assemble truly complete, gapless genome sequences from a variety of species.


What is it?

  • It is an innovative software for assembling complete, gapless diploid genomes.
  • It is developed by researchers from National Institutes of Health (NIH), US.
  • Verkko grew from assembling the first gapless human genome sequence, which was finished last year by the Telomere-to-Telomere (T2T) consortium, a collaborative project funded by the National Human Genome Research Institute (NHGRI), part of NIH, USA.


How Verkko works?

  • Different DNA sequencing technologies generate different types of genomic puzzle pieces. Some are small and highly detailed, while others are much bigger though the image is blurry.
  • Verkko compares and assembles both types of pieces to generate a complete and accurate picture.
  • Verkko starts by putting together the small, detailed pieces, creating many partially assembled but disconnected segments of sequence.
  • Then, Verkko compares the assembled regions with the larger, less precise pieces.
  • These larger pieces serve as a framework to order the more detailed regions.
  • The final product is an accurate and complete genome sequence.



  • This software makes the process of assembling complete genome sequences more affordable and accessible.
  • It will also accelerate efforts to generate gapless genome sequences of species commonly used in research.