Mitochondrial Replacement Therapy

The Human Fertilisation and Embryology Authority (HFEA), the U.K. fertility regulator, recently confirmed that less than five children have been born using mitochondrial replacement therapy (MRT) as of April 2023.

Details –

In 2015, the United Kingdom became the first country to regulate mitochondrial replacement therapy (MRT).

About Mitochondrial Replacement Therapy (MRT) –

• It is a new form of reproductive in-vitro fertilisation (IVF) which works on the principle of replacing a women’s abnormal mitochondrial DNA (mt-DNA) with the donor’s healthy one.
• Why is MRT done?
  • • People have two types of DNA in their cells, nuclear DNA, which is inherited from both parents and mitochondrial DNA (mtDNA), which is inherited only from the mother.
    • MRT is designed to prevent women who are carriers of mitochondrial diseases from passing on these heritable genetic diseases to their children.
• How is MRT carried out?
  • • MRT involves using an egg from an egg donor who doesn’t have mutations.
    • The nucleus of the egg is removed and replaced with the nuclear DNA from the woman who has mitochondrial DNA mutations.
    • The egg is then fertilised with the father’s sperm in the embryology lab.
    • If it grows into an embryo for transfer during IVF treatment, the embryo would be free of mitochondrial disease. 

What is in-vitro fertilisation (IVF)?

• It is a type of assisted reproductive technology (ART) where sperm and an egg are fertilised outside of the human body.
• IVF is a complex process that involves retrieving eggs from ovaries and manually combining them with sperm in a lab for fertilisation.
• Several days after fertilisation, the fertilised egg (now called an embryo) is placed inside a uterus. Pregnancy occurs when this embryo implants itself into the uterine wall.

What is Mitochondria?

• Mitochondria are membrane-bound cell organelles that generate most of the chemical energy needed to power the cell’s biochemical reactions.
• Mitochondria are often referred to as the powerhouses of the cell.
• Chemical energy produced by the mitochondria is stored in a small molecule called adenosine triphosphate (ATP). ATP is the chemical energy “currency” of the cell that powers the cell’s metabolic activities.
• Generally, mitochondria, and therefore mitochondrial DNA, are inherited only from the mother.